Mr. Justice Harlan,

after making the foregoing statement, delivered the opinion of the court.

We pass without extended discussion the suggestion that the particular section of the statute of Massachusetts now in question (§ 137, c. 75) is in derogation of rights secured by the Preamble of the Constitution of the United States. Although'that Preamble indicates the. general purposes for which the people ordained and established the Constitution,. it has never been regarded as the source of any substantive power conferred on the Government of the United States or on any of its Departments. Such powers embrace only those expressly granted in the body of the Constitution and such as may be implied from those, so granted. Although, therefore, one of the declared objects of the. Constitution was to secure the blessings of liberty to all under the sovereign jurisdiction and authority of the United States, no power can be exerted to that end by the United States unless, • apart from the Preamble, it be found in some express delegation of power or in some power to be properly implied therefrom. 1 Story’s Const. § 462.

We also pass without discussion the suggestion that the above section of the statute is opposed to the spirit of the Constitution. ’ Undoubtedly, ás observed by Chief Justice Marshall, speaking for the court in Sturges v. Crowninshield, 4 Wheat. 122, 202, “the spirit of an instrument, especially of a constitution, is to be respected not less than its letter, yet the spirit is to be collected chiefly from its words.” ' We have no need in this case to go beyond the plain, obvious meaning of the words in those provisions of the Constitution which, it is contended, must control our decision.

What, according to the judgment of the state court, is the *23.scope ánd-effect of the statute? What results were intended to be accomplished by it? These questions must be answered.

The Supreme Judicial Court .of Massachusetts said in the present case: “Let us consider the offer of evidence which was made by the defendant Jacobson. The ninth of the propositions which he offered to prove, as to what vaccination consists of, is nothing more than a fact of common knowledge, upon which the statute is founded, and proof of it was unnecessary and immaterial. The thirteenth and fourteenth involved matters depending upon his personal opinion, which could not be taken as correct, or given 'effect, merely because he made it a ground of refusal to comply with the requirement. Moreover, his views could not affect the validity of the statute, nor entitle him to be excepted from its provisions. Commonwealth v. Connelly, 163 Massachusetts, 539; Commonwealth v. Has, 122 Massachusetts, 40; Reynolds v. United States, 98 U. S. 145; Regina v. Downes, 13 Cox C. C. 111. The other eleven .propositions all relate to alleged injurious or dangerous effects of vaccination. The defendant ‘offered to prove and show by competent evidence’ these so-called facts. Each of them, in its nature, is such that it cannot be stated as a truth, otherwise than as a matter of opinion. The only ‘competent evidence’ that could be presented to the court to prove these propositions was the testimony of experts, giving their opinions. It would not have been competent to introduce the medical history of individual cases. Assuming that medical experts'could have been found who would have testified in support of these propositions, and that it had become the duty of the judge, in accordance with the law as stated in Commonwealth v. Anthes, 5 Gray, 185, to instruct the jury as to whether or not the statute is constitutional, he would have been obliged to consider the evidence in connection with facts of common knowledge, which the court will always regard in passing upon the constitutionality of a statute. • He would have considered this testimony of experts in connection with the facts that for nearly a century most of the members of the medical profession *24have regarded vaccination, repeated after intervals, as a preventive of smallpox; that while they have recognized the possibility of injury to an individual from carelessness in the performance of it, or even in a conceivable, case without carelessness, they generally have considered the risk of such an' injury too small to be seriously weighed as against the benefits coming from the discreet and proper use of the preventive; and that not only the medical profession and the people generally have for . a long time entertained these opinions, but legislatures and courts have acted upon them with general unanimity. If the defendant had been permitted to introduce such expert testimony as he had in support of these several propositions, it could not have changed the result. It would' not have justified the court in holding that- the legislature had transcended its power in enacting this statute, on their judgment of what the welfare of the people demands.” Commonwealth v. Jacobson, 183 Massachusetts, 242.

-. While the mere rejection of defendant’s offers of proof does not strictly present a Federal question, we may properly regard the. exclusion of evidence upon the ground of its irico'mpetency or immateriality under the statute as showing what, in “the opinion of the state court, is the scope and meaning of the statute. Taking the above observations of the state' court as indicating the scope of the statute — and such is our duty, Leffingwell v. Warren, 2 Black, 599, 603, Morley v. Lake Shore Railway Co., 146 U. S. 162 167, Tullis v. L. E. & W. R. R. Co., 175 U. S. 348, W. W. Cargill Co. v. Minnesota, 180 U. S. 452, 466—we assume for the purposes of the present inquiry that its provisions require, at least1 as a general rule", that adults not under guardianship and remaining within the limits of the city of Cambridge must submit, to the regulation adopted by the Board of Health. Is the statute, so construed, therefore, inconsistent with the liberty which "the Constitution of the United States secures to every person*'against deprivation by the State? . ’

The authority of the State to enact this statute is to be *25referred to what is commonly called the police power — a power which the State did not surrender when becoming a member of the Union under .the Constitution. Although this court has refrained from any attempt to define the limits of that power, yet it has distinctly recognized the authority of a State to enact .quarantine laws and “health-laws of every description;” indeed, all laws that relate to matters completely within its territory and which do not by their, necessary operation affect the people of other States. According to settled principles the police power of a State must be held to embrace, at least, such reasonable regulations established directly by legislative enactment as will protect the publi'c health and the public safety. Gibbons v. Ogden, 9 Wheat. 1, 203; Railroad Company v. Husen, 95 U. S. 465, 470; Beer Company v. Massachusetts, 97. U. S. 25; New Orleans Gas Co. v. Louisiana Light Co., 115 U. S. 650, 661; Lawton v. Steele, 152 U. S. 133. It is equally true that the State may invest local bodies called into existence 'for purposes of local administration with authority in some appropriate way ,to safeguard the public health and the public safety. The mode or manner in which those results are to be accomplished is within the discretion of the State, subject, of course, so far as Federal power is concerned, only to the condition that no rule prescribed by a State, nor any regulation adopted by a local governmental - agency acting under the sanction of state legislation, shall contravene the Constitution-of the United States or infringe any right granted or secured by that- instrument. A local enactment or regulation, even if based on the acknowledged police powers of a State, must always yield in case of conflict with the exercise by the General Government of any power it possesses under the Constitution, or with any right which that instrument gives or secures. Gibbons v. Ogdon, 9 Wheat. 1, 210; Sinnot v. Davenport, 22 How. 227, 243; Missouri, Kansas & Texas Ry. Co. v. Haber, 169 U. S. 613, 626.

We come, then, to inquire whether any right given, or secured by the Constitution,' is invaded :by the statute as in*26terpreted by the state court. The defendant insists that his liberty is invaded when the State subjects him to fine or imprisonment for neglecting or refusing to submit to vaccination; that a compulsory vaccination law is unreasonable, arbitrary and oppressive, and, therefore, hostile to the inherent right of every freeman to care for his own body and health in such way as to him seems best; and that the'execution of such a law against one who objects to vaccination, no matter'for what reason, is nothing short of an assault upon his person. But the liberty secured by the Constitution of the United States to every person within its jurisdiction does not import an absolute right in each person to be, at all times and in all circumstances, wholly freed from restraint. There are manifold restraints to which every person is necessarily subject for the common good. On any other basis organized society could not exist with safety to its members. Society based on the rule that each one is a law unto himself would soon' be confronted with disorder and anarchy. Beal liberty .for all could not exist under the operation of a principle which recognizes the right of each individual person to use his own, whether in respect of his person or his property, regardless of the injury that may be done to others. This court has more than once recognized it as a fundamental principle that “persons and property are subjected to all kinds of restraints and burdens, in order to secure the general comfort, health, and prosperity of the State; of the perfect right of the legislature to do which no question ever was, or upon acknowledged general principles ever can be made, so far as natural persons are concerned.” Railroad Co. v. Husen, 95 U. S. 465, 471; Missouri, Kansas & Texas Ry. Co. v. Haber, 169 U. S. 613, 628, 629; Thorpe v. Rutland & Burlington R. R., 27 Vermont, 140, 148. In Crowley v Christensen, 137 U. S. 86, 89, we.^aid: “The possession and •enjoyment of all rights are subject to such reasonable conditions as may be deemed by the governing authority of the country essential to the safety, health, peace, good order and morals of the community. Even liberty *27itself, the greatest of all rights, is not unrestricted license to act according to one’s own will. It is only freedom from restraint under conditions essential to the equal enjoyment of the same right by others. It is then liberty regulated by law.” . In the constitution of Massachusetts adopted in 1780 it was laid down as a fundamental principle of the social compact that the whole people covenants with each citizen, and each citizen with the whole' people, that all shall be governed by certain. laws for "the common good,” and that government is instituted "for the common good, for the protection, safety, prosperity and happiness of the people, and not for the profit, honor or private interests of any one man, family or class of men.” The good'and welfare of'the Commonwealth, of which the legislature is primarily the judge, is the basis on which the police power rests iii Massachusetts. Commonwealth v. Alger, 7 Cush. 53, 84.

Applying these principles to the present case; it is to be obserVed that the legislature of Massachusetts required the inhabitants of a city or town to be vaccinated only when, in the opinion of the Board of Health, that was necessary for the public health or the public safety. The authority to determine for all what ought to be done in such an emergency must have been lodged somewhere or in some body; and surely it was appropriate for the legislature to refer that question, in the first instance, to a Board of Health, composed of persons residing in the locality affected and appointed, presumably, because of their fitness to determine such questions. To invest such a body with authority over such matters was not an unusual nor an unreasonable or arbitrary requirement. Upon the principle of self-defense, of paramount necessity, a community has the right to protect itself against an epidemic of disease which threatens the safety of its members. It is to be observed that whén the regulation in question was adopted, smallpox, according to the recitals in the regulation adopted by the Board of Health, was prevalent to some extent in the city of Cambridge and the disease was increasing. If such was *28the situation — and nothing is asserted or appears in the record to the contrary — if we are to attach any value whatever to the knowledge which, it is safe to affirm, is common to all civilized peoples touching smallpox and the methods most usually employed to eradicate that disease, it cannot be adjudged that the present regulation of the Board of Health was not necessary in order to protect the public health and secure the public safety. Smallpox being prevalent and increasing' at Cambridge, the court would usurp the functions of another branch of government if it adjudged, as matter of law, that the mode adopted under the sanction of the State, to protect the people at large,, was arbitrary and not justified by the necessities of the case. We say necessities of the case, because it might be that an acknowledged power of a local community to protéct itself against an .epidemic threatening the safety of all, might be exercised in particular circumstances and in reference to particular persons in such an arbitrary, unreasonable manner, or might go so far beyond what was reasonably required for .the safety of the public, ás to authorize or compel the courts to interfere for the protection of such persons. Wisconsin &c. R. R. Co. v. Jacobson, 179 U. S. 287, 301; 1 Dillon Mun. Corp., 4th ed.,§§ 319 to 325, and authorities in notes; Freund’s Police Power, § 63 et seq. In Railroad Company v. Husen, 95 U. S. 465, 471-473, this court recognized the right of a State to pass sanitary laws, laws for the protection of life, liberty, health or property within its limits, laws to prevent persons and animals suffering under contagious or infectious diseases, or convicts, from coming within its borders. But as the laws ■there involved went beyond the necessity of the case and under the guise of exerting a police power invaded the domain of Federal authority and violated rights secured by the Constitution, this court deemed it to be its duty to hold such laws invalid. If the mode adopted by the .Commonwealth of Massachusetts for the protection of its local communities against smallpox proved to be distressing, inconvenient or objectionable to some — if nothing more could be reasonably *29affirmed of the statute in question — the answer is that it was the duty of the constituted authorities primarily to keep in view the welfare, comfort and safety of the many, and not per-v. mit the interests of the' many to be subordinated to the wishes . or convenience of the few. There is, of course, a sphere within which the individual may assert the supremacy of his own will and rightfully dispute the authority of any human government, especially of any free government existing under a written constitution, to interfere with the exercise of that will. But it is equally true that in every well-ordered society charged with the duty of conserving the safety of its members the rights of the individual in respect of his liberty may at times, under the. pressure of great ■ dangers, be subjected to such restraint, to be enforced by reasonable regulations, as-the safety of the general public may demand. An American citizen, arriving at an American port on a vessel in which, during , the voyage, there ha,d been, cases of yellow fever or Asiatic choléra, although apparently free from disease himself, may yet, in some circumstances, be held in quarantine against his will on board of such vessel or in a quarantine' station, until it be ascertained by inspection, conducted with due diligence, that the danger of the spread of the disease among the community at large has disappeared. The liberty secured by the Fourteenth Amendment, this court has said, consists, in part, in. the right of a .person “to. live and work where he will,” Allgeyer v. Louisiana, 165 U. S. 578, and yet he may be compelled, by force if need be, against his will and without regard to his personal wishes or-his pecuniary interests, or even his religious or political convictions, to take his place in the ranks of the army of his country and risk the chance of being shot down in its defense. It is not, therefore, true that the power of the public to guard itself against imminent danger depends in every case involving the control of one’s body upon his willingness to submit to reasonable regulations established by the constituted authorities, under the *30sanction of. the State, for the purpose of protecting the public collectively against such danger.

It is said, however, that the statute, as interpreted by the state court, although making an exception in favor of children certified by a registered physician to be unfit subjects for vaccination, makes no exception in the case of adults in like condition. But this cannot be deemed a denial of the equal protection of the laws to adults; for the statute is applicable equally to all in like condition and there are obviously reasons why regulations may be appropriate for adults which could not be safely applied to persons of tender years.

Looking at the propositions embodied in the defendant’s rejected offers of proof it is clear that they are more formidable by' their number than by their inherent value. Those offers in the main seem to have had.no purpose except to state the general theory of those of the medical profession who attach little or no value to vaccination as- a means of preventing the spread of smallpox'or who think that vaccination causes other diseases of the body. What everybody knows the court must know, and therefore the state court judicially knew, as this court knows, that an opposite theory accords with the common belief and is maintained by high medical authority. We must assumé' that when the statute in question was passed, the legislature of Massachusetts was not unaware of these opposing theories, and was compelled, of necessity, to choose be-, tween .them. It was not compelled to commit a matter involving the public health and safety to the final decision of a court or jury. . It is no part of the function of a court or a jury to determine which one of two modes was likely to be the most effective for the protection of the public against disease. That was for the legislative department to determine in the light of all the information it had or could obtain. It could not properly abdicate its function to guard the public health and safety. The state legislature proceeded upon the theory which recognized vaccination as at least an effective if not the best known way in which to meet and suppress the *31evils of a smallpox epidemic that imperilled an'entire population. Upon what sound principles as to the relations existing between the different departments of government can the court review this action of the legislature? If there is any such power in the judiciary to review legislative action in respect of a matter affecting the general welfare, it can only be whén that which the legislature has,done comes within the rule that if a statute purporting to have been enacted to protect the public •. health, the public morals or the public safety, has no real or substantial relation to those objects, or is, beyond all question, a plain, palpable invasion of rights secured by- the fundamental law, it is the duty of the courts .to so adjudge, and thereby give effect to the Constitution.” Mugler v. Kansas, 123 U. S. 623, 661; Minnesota v. Barber, 136 U. S. 313, 320; Atkin v. Kansas, 191 U. S. 207, 223.

Whatever may be thought of the expediency of this statute, it cannot be affirmed to.be, beyond question, in palpable conflict with the Constitution. . Nor, in view of the methods employed to stamp out the disease of smallpox, can anyone confidently assert that the means prescribed by the State to that end has no real or substantial relation' to the protection of the public health and the public safety. Such an assertion would not be consistent with the experience of this and other countries’ whose authorities have dealt with the disease of smallpox.1 And the principle of vaccination as a means to *32prevent the spread of smallpQx has been enforced in many States by statutes making the vaccination of children a condition of their right to enter or remain in public schools. Blue v. Beach, 155 Indiana, 121; Morris v. City of Columbus, 102 *33Georgia, 792; State v. Hay, 126 N. Car. 999; Abeel v. Clark, 84 California, 226; Bissell v. Davidson, 65 Connecticut, 183; Hazen v. Strong, 2 Vermont, 427; Duffield v. Williamsport School District, 162 Pa. St. 476.

*34The latest case upon the subject of which we are aware is Viemeister v. White, President &c., decided very recently by the Court of Appeals of New York, and the opinion in which has not yet appeared in the regular reports. That case involved the validity of a statute excluding from the public schools all children who had not been vaccinated. One contention was that the statute and ,the regulation adopted in exercise of its provisions was inconsistent with the rights, privileges and liberties of the citizen. The contention was overruled, the court saying,.among other things: “Smallpox is known of all to be a dangerous and contagious disease. If vaccination strongly tends to prevent the transmission or spread of this disease, it logically follows that children may be refused admission to the public schools' until they have, been vaccinated. The appellant claims that vaccination does not tend to prevent smallpox, but tends to bring about other diseases, and that it does much harm, with nó good.

“ It must be-conceded that spme laymen, both learned and unlearned, and some physicians of great skill and repute, do not believe that vaccination is a preventive of smallpox. The common belief, however, is that it has a decided’ tendency to prevent the spread of this fearful disease and to render it less dangerous to those who contract it. While not accepted by all, it is accepted by the mass of the people, as well as by most members of the medical profession. It has been- general in our State and in most civilized nations for generations. It is *35generally accepted in theory and generally applied in practice, both by the voluntary action of the people and in obedience to the command of law. Nearly every State of the Union has statutes to encourage, or directly .or indirectly to require, vaccination, and this is true of most nations of Europe. ■. . .

. “ A common belief, like, common knowledge, does not require evidence to establish its existence, but may be acted upon without proof by the legislature and the courts. . . .

“ The fact that the belief is not universal is not controlling, for there- is scarcely -any helief that is accepted by everyone. The possibility that the belief may be wrong, and that science may yet show it to be wrong, is not conclusive; for the legislature has the right to pass laws which;- according to the common belief of the people, are adapted to prevent the spread of contagious diseases. In a free country, where the government is by the people, through their chosen representatives, practical legislation admits of no other standard of action; for what the. people believe, is for the common welfare must be accepted as tending to promote the common welfare, whether it does in fact or not.. Any other basis would conflict with the spirit of the Constitution, and would sanction measures opposed to a republican form of government. While we do not decide and cannot decide that vaccination is a preventive of smallpox, we take judicial notice of the fact .that this is the common belief of the people of the State, aind with this fact as a foundation we hold that the statute in question is a health law, enacted in a reasonable and proper exercise of the police power.”- 72 N. E. Rep. 97.

Since then vaccination, as a means of protecting a community against smallpox, finds strong support in the experience of this and other countries, no court, much less a jury, is justified in disregarding the action of the legislature simply because in -its or their opinion that particular method was— perhaps or possibly — noUthe best either for children or adults.

Did the. offers of proof made by the defendant present a case which; entitled him, while remaining in Cambridge, to *36claim exemption from the operation of the statute and of the regulation adopted by the Board of Health? We have already said that his rejected offers, in the main, only set forth the theory of those who had no faith in vaccination as a means of preventing the spread of smallpox, or who thought that vaccination, without benefiting the public, put in peril the health of the person vaccinated. But there were some offers which it is contended embodied distinct facts that might properly have been considered. Let us see how this is.

The defendant offered to prove that vaccination “quite often” caused serious and'permanent injury to the health of the person vaccinated; that the operation “occasionally” resulted in death; that it was “impossible” to tell “in any particular case” what the results of vaccination would be or whether it yould injure the health- or result in death; that “quite often” one’s blood is in a certain condition of impurity when it is not prudent or, safe to vaccinate him; that there is no practical test by which to determine “with any degree of certainty” whether one’s blood is in such condition of impurity as to render vaccination necessarily unsafe or dangerous; that vaccine matter is “quite often” impure and dangerous to -be used, but whether impure or not cannot be ascertained by any known practical test; that the defendant refused to submit to vaccination for the reason that he had, “when a child,” been caused great and extreme suffering for a long period by a disease produced by vaccination; and that' he had witnessed a similar result of vaccination not only in the case of his son, but in the cases of others.'

These offers, in effect, invited -the court and jury to go over-the whole ground gone over by the legislature when it enacted the statute in question. The legislature assumed that some children, , by reason of their condition at the- time, might not be fit subjects of vaccination; and it is suggested — and we will not say without reason — that such is the case with some adults. But the defendant did not offer to prove that, by reason of his then condition, he was in fact not a fit subject of-vaccination *37at the time he was informed of the requirement of the regulation adopted by the Board of Health. It is entirely consistent with his offer of proof that, after reaching full age he had become, so far as medical skill could. discover, and when informed of the regulation of the Board of Health was, a fit subject of vaccination, and that, the vaccine matter to be used in his case was such as any medical practitioner of good standing would regard as proper to be used. The matured opinions of medical men-everywhere, and the experience of mankind, as all must know, negative the suggestion that it is not possible in any case to determine whether vaccination is safe. Was defendant exempted from the operation of the statute simply because* of his dread of the same evil results experienced by him when .a child and had observed in the cases of his son and other children? Could he reasonably claim such an exemption because “quite often” or “occasionally” injury had resulted from vaccination, or because it was impossible, in the opinion of some, by any practical test, to determine with absolute certainty-whether a particular person could be safely vaccinated?

It seems to the court that an affirmative answer to these questions would practically -strip the legislative department of its function to care for the public health and the public safety when endangered by epidemics of disease. Such an answer would mean that compulsory vaccination could not, ■in- any conceivable case, be legally enforced in a community, even at the command of the legislature, however widespread the epidemic of smallpox, and however deep and universal was the belief of the community and of. its medical advisers, that a system of general vaccination was vital to the safety of all.

We are not prepared to hold that a minority, residing or •remaining in any city or town where smallpox is prevalent, and enjoying the general protection afforded by'an organized local government, may thus defy the will of its constituted authorities, acting in good faith for all, under the legislative sanction of. the State. If such be the privilege of a minority

*38then a. like privilege would belong to each individual of the community, and the spectacle would be presented of the welfare and safety of- an entire population being subordinated to the notions of a single individual who chooses to remain a part of that population. We are unwilling to hold it to be. an element in the liberty secured by the Constitution of the United States that one person, or a minority of persons, residing in any community and enjoying the -benefits of its local government, should have the power thus to dominate the majority when supported in their action by the authority of the State. While this court should guard with firmness every right appertaining to life, liberty or property as secured to the individual by the Supreme Law of the Land, it is of the last importance that it should not invade the domain of local' authority' except when it is plainly necessary to do so in order to enforce that law. The safety and the health of the people of Massachusetts are, in the -first instance, for that Commonwealth to guard and protect. They are matters that do not ordinarily concern the National Government. So far as they can be reached by any government, they depend, primarily, upon such action as the State in its wisdom may take; and we do not perceive that this legislation has invaded any right secured by the Federal Constitution.

Before closing this opinion we deem it appropriate, in order to prevent misapprehension, as to our views, to observe— perhaps to repeat a thought already sufficiently expressed, namely — that the police power of a State, whether exercised by the legislature, or by a local body acting under its authority, may be exerted in such circumstances or by regulations so arbitrary and oppressive in particular cases as to justify the interference of the courts to prevent wrong and oppression. Extreme cases can be readily suggested. Ordinarily such cases are -not safe guides in the administration of the law. It is easy; for instance, to suppose the case of an adult who is embraced by the mere words of the act, but yet to subject whom to vaccination in a particular condition of his health *39or body, would be cruel and inhuman in the last degree. We are not to be understood' as holding that the statute ^was intended to be applied to such a case, or, if it was so intended, • that the judiciary would not be competent to interfere and protect the health and life of the individual concerned. “All laws,” this court has said, “should receive'a sensible construction. General terms should be so limited in their application as not to lead to injustice, oppression or absurd consequence! It will always, therefore, be presumed that the legislature intended exceptions to its language which would avoid results of that character. The reason of the law in such cases should prevail over its letter.” United States v. Kirby, 7 Wall. 482;. Lau Ow Bew v. United States, 144 U. S. 47, 58. Until otherwise informed by the highest court of Massachusetts we are not inclined to hold that the statute establishes the absolute rule that an adult must be vaccinated if it be apparent or can be shown with reasonable certainty that he is not' at the time a fit subject of vaccination or that vaccination, by reason of his then condition, would seriously impair his health or probably cause his death. No such case is here presented. It is the case of an adult who, for aught that appears, was himself in perfect health-and a fit subject of vaccination, and yet,' while remaining in the community, refused to obey the statute and' the regulation adopted in execution of its provisions -for the protection of the public- health and the pubjic safety, confessedly endangered by the presence of a dangerous disease.

. We now decide only that the statute covers the present case, • and that nothing clearly appears that would justify this court in holding it to be unconstitutional and inoperative in its application to the. plaintiff in error.

The judgment of the court below must be affirmed.

It is 'so ordered.

Mr. Justice Brewer and Mr. Justice Peckham dissent.'